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SUPT6H Polyclonal Antibody, Bethyl Laboratories
SDP

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A300801AT

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Catalog No. 50-155-8481



Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.
Specifications

Specifications

SUPT6H
Polyclonal
TBS with 0.1% BSA and 0.09% sodium azide
Q62383, Q7KZ85
Supt6, SUPT6H
Between 425 and 475
20 μL
Primary
Human, Mouse
Antibody
IgG
Immunohistochemistry, Western Blot
Unconjugated
SUPT6H
KIAA0162, MGC87943, SPT6, SPT6H, emb-5, hSPT6; tat-CT2 protein; tat-cotransactivator 2 protein; transcription elongation factor SPT6
Rabbit
Antigen affinity chromatography
RUO
20926, 6830
4° C
Liquid
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